If you are using Mac OS X and want to run Windows applications, the most popular option is to install Windows OS using Bootcamp, or run Windows in a virtual machine. Linux users will know that you can use Wine to install and run Windows applications natively. The good news is that Mac users can run Wine to install Windows applications as well. Wineskin is a Wine-tool ported over to the Mac platform. Check out how you can run Windows applications on Mac OS X.

Wineskin is simply an implementation of Wine at its core. For those who are not sure what Wine (an acronym for “Wine Is Not an Emulator”) is, it is a compatibility layer capable of running Windows applications on several POSIX-compliant operating systems, including Linux and Mac OS X.

Full article here:
Easily Run Windows Applications on Mac OS X (Make Tech Easier)
Related:
Wineskin: Run Windows Software On Mac OS X Without An Emulator [Mac] (MakeUseOf)